James L Flowers Selected Research

Camptothecin

4/2011	BACPTDP: a water-soluble camptothecin pro-drug with enhanced activity in hypoxic/acidic tumors.
1/2006	Camptothecin analogs with enhanced activity against human breast cancer cells. II. Impact of the tumor pH gradient.
1/2006	Camptothecin analogs with enhanced activity against human breast cancer cells. I. Correlation of potency with lipophilicity and persistence in the cleavage complex.
9/2003	The activity of camptothecin analogues is enhanced in histocultures of human tumors and human tumor xenografts by modulation of extracellular pH.

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James L Flowers Research Topics

Disease

3	Neoplasms (Cancer) 04/2011 - 09/2003
2	Neuroblastoma 04/2011 - 09/2003
2	Breast Neoplasms (Breast Cancer) 01/2006 - 01/2006
1	Pancreatic Neoplasms (Pancreatic Cancer) 04/2011
1	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 06/2005

Drug/Important Bio-Agent (IBA)

4	CamptothecinIBA 04/2011 - 09/2003
3	2- cyclohexylidenhydrazo- 4- phenyl- thiazoleIBA 01/2006 - 09/2003
2	AcidsIBA 04/2011 - 01/2006
2	Alkylating AgentsIBA 01/2006 - 01/2006
2	Hormones (Hormone)IBA 01/2006 - 01/2006
2	Pharmaceutical PreparationsIBA 06/2005 - 09/2003
1	Topoisomerase InhibitorsIBA 04/2011
1	7-butyl-10-amino-camptothecinIBA 04/2011
1	ProdrugsIBA 04/2011
1	Proteins (Proteins, Gene)FDA Link 01/2006
1	Nucleic AcidsIBA 01/2006
1	Propidium (Propidium Iodide)IBA 01/2006
1	10-aminocamptothecinIBA 01/2006
1	Gemcitabine FDA Link 06/2005
1	Antineoplastic Agents (Antineoplastics)IBA 09/2003

Therapy/Procedure

1	Drug Therapy (Chemotherapy) 01/2006